8-OHDPAT-Induced Disruption of Prepulse Inhibition in Rats is Attenuated by Prolonged Corticosterone Treatment
| Autor: | Krzysztof Wędzony, Katarzyna Fijał, A Gadek-Michalska, Agnieszka Chocyk, Anna Czyrak, Marzena Maćkowiak |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Reflex Startle Serotonin medicine.medical_specialty Time Factors medicine.medical_treatment Anti-Inflammatory Agents Multiple dose Hippocampus Piperazines chemistry.chemical_compound Corticosterone Internal medicine Adrenal Glands medicine Animals Drug Interactions RNA Messenger In Situ Hybridization Prepulse inhibition 5-HT receptor Pharmacology 8-Hydroxy-2-(di-n-propylamino)tetralin Binding Sites Dose-Response Relationship Drug Body Weight Neural Inhibition Organ Size Hydroxyindoleacetic Acid Rats Serotonin Receptor Agonists Psychiatry and Mental health Steroid hormone Endocrinology Gene Expression Regulation Mechanism of action chemistry Receptors Serotonin Autoradiography Raphe Nuclei 5-HT1A receptor Serotonin Antagonists medicine.symptom Raphe nuclei Receptors Serotonin 5-HT1 |
| Zdroj: | Neuropsychopharmacology. 28:1300-1310 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/sj.npp.1300165 |
| Popis: | The present study investigated the impact of acute and repeated administrations of corticosterone (10 mg/kg, twice daily, for 7 days) on serotonin (5-HT)(1A) receptor function, density and expression. The effect on 5-HT(1A) receptor function was assayed in rats by assessing the corticosterone-induced modulation of disruption of prepulse inhibition (PPI) of acoustic startle response induced by 8-OHDPAT, a 5-HT(1A) receptor agonist. Our experiments revealed that repeated but not acute treatment with corticosterone attenuated the 8-OHDPAT-evoked disruption of PPI without having any effect on PPI or startle amplitude alone. Chronic corticosterone treatment modulated also the neuronal activity of serotonergic pathways in the brain decreasing the level of 5-HIAA in the raphe nuclei and increasing both 5-HT and 5-HIAA levels in the hippocampus. Nevertheless, the effects of 8-OHDPAT on 5-HT metabolism were not changed by corticosterone. However, 5-HT(1A) receptor binding in the ventral hippocampus and entorhinal cortex but not in the raphe nuclei was decreased after chronic corticosterone treatment. It is concluded that chronically elevated corticosterone level is capable of inducing functional desensitization of 5-HT(1A) receptors which is paralleled by decreases in the 5-HT(1A) receptor binding in the ventral hippocampus and entorhinal cortex, the brain structures shown to be engaged in the regulation of PPI. Alterations in 5-HT(1A) receptors may be one of important mechanisms by which glucocorticoids/stress influence various psychiatric conditions. |
| Databáze: | OpenAIRE |
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