Antiosteoporotic effects of benzylbenzoate glucosides from Curculigo orchioides in ovariectomized rats
| Autor: | Lu-Ping Qin, Yan Nie, Hai-Liang Xin, Ting Han, Yuan-hui Guo, Qiao-Yan Zhang, Lei Liu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Antioxidant Ovariectomy medicine.medical_treatment Bone tissue Benzoates Antioxidants Rats Sprague-Dawley Excretion Curculigo chemistry.chemical_compound Glucosides Bone Density Internal medicine medicine Animals Femur Bone mineral chemistry.chemical_classification biology Chemistry Glutathione peroxidase biology.organism_classification Malondialdehyde Rats Curculigo orchioides medicine.anatomical_structure Endocrinology Complementary and alternative medicine Ovariectomized rat Osteoporosis Calcium Female Drugs Chinese Herbal |
| Zdroj: | Journal of Chinese Integrative Medicine. :1419-1426 |
| ISSN: | 1672-1977 |
| Popis: | OBJECTIVE To evaluate the antiosteoporotic effects of benzyl benzoate glucosides from Curculigo orchioides (COBG) in ovariectomized (OVX) rats. METHODS A total of 70 female Sprague-Dawley rats were assigned to sham-operated and OVX model groups. The OVX rats were further divided into six subgroups treated by gavage with vehicle, 1 mg/kg of nylestriol, 6, 18 and 54 mg/kg of COBG and 3.0 g/kg of ethanol extract of Curculigo orchioides respectively for 12 weeks. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. The sections of tibia were prepared for histomorphometric analysis. The biomarkers in serum and urine were determined using reagent kits. RESULTS Ovariectomy induced the bone loss and microarchitectural deterioration of bone tissue with the activities of increased serum alkaline phosphatase and loss of calcium through the excretion in urine, and decreased levels of antioxidant in serum (P |
| Databáze: | OpenAIRE |
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