The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host–pathogen interactions

Autor:	Benjamin Samuel Orozco, Roanna London, Eleftherios Mylonakis
Rok vydání:	2006
Předmět:	Cryptococcus neoformans Virulence biology fungi General Medicine Moths biology.organism_classification Dictyostelium Applied Microbiology and Biotechnology Microbiology Galleria mellonella Drosophila melanogaster Animals Humans Acanthamoeba castellanii Caenorhabditis elegans Pathogen
Zdroj:	FEMS Yeast Research. :060720072718039
ISSN:	1567-1364 1567-1356
DOI:	10.1111/j.1567-1364.2005.00056.x
Popis:	Analysis of the molecular mechanisms by which a pathogen interacts with the human host is most commonly performed using a mammalian model of infection. However, several virulence-related genes previously shown to be involved in mammalian infection with Cryptococcus neoformans have also been shown to play a role in the interaction of these pathogens with invertebrates, such as Acanthamoeba castellanii, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster and Galleria mellonella. The study of host-pathogen interactions using these model hosts has allowed rapid screening of mutant libraries and can be used for the study of evolutionarily preserved aspects of microbial virulence and host response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82826013ba4f21ed5183060a835b0389 https://doi.org/10.1111/j.1567-1364.2005.00056.x Zobrazit plný text záznamu Plný text