Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27
| Autor: | Ana Lúcia Fachin, Thaise Graminha Lucas, Ana Laura Mendes Lourenço, Carlos Roberto Polaquini, Marcelo Engracia Garcia, Luis Octávio Regasini, Lucélio B. Couto, Bianca Vieira de Andrade, Gabriel da Silva, Guilherme Silva Torrezan, Suzelei C. França, Reinaldo B. Bestetti, Viviane Seba, Mozart Marins, Felipe Teixeira Lima |
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| Přispěvatelé: | Univ Ribeirao Preto, Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer therapy Pharmaceutical Science Antineoplastic Agents Matrix metalloproteinase migration Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry Cell Movement Stomach Neoplasms Cell Line Tumor Drug Discovery medicine Humans Neoplasm Invasiveness curcumin Physical and Theoretical Chemistry Survival rate Gastric cancer cell Collagenase activity Cell Proliferation Dose-Response Relationship Drug Chemistry Communication gastric cancer Organic Chemistry apoptosis Cancer medicine.disease invasion 030104 developmental biology matrix metalloproteinase 2 Chemistry (miscellaneous) Apoptosis 030220 oncology & carcinogenesis Cancer research Curcumin Molecular Medicine |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Molecules, Vol 23, Iss 2, p 279 (2018) Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry |
| ISSN: | 1409-6900 |
| Popis: | Made available in DSpace on 2018-11-26T17:48:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-02-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Ministry of Education (Programa de Educacao Tutorial) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy. Univ Ribeirao Preto, Biotechnol Unit, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP, Brazil Univ Ribeirao Preto, Med Sch, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP, Brazil Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Lab Green & Med Chem, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Lab Green & Med Chem, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil CNPq: 471129/2013-5 CNPq: 306251/2016-7 FAPESP: 2014/18330-0 FAPESP: 2014/15307-7 FAPESP: 2017/03237-2 |
| Databáze: | OpenAIRE |
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