Erythroid microRNA and oxidant status alterations in l-thyroxine-induced hyperthyroid rats: effects of selenium supplementation
| Autor: | Aysun Yoldas, Yavuz Abbak, Nuran Dariyerli, Nurten Bahtiyar, Selmin Toplan |
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| Rok vydání: | 2021 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Antioxidant endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment chemistry.chemical_element 030209 endocrinology & metabolism medicine.disease_cause Hyperthyroidism Superoxide dismutase Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Selenium 0302 clinical medicine Endocrinology Internal medicine Male rats Internal Medicine medicine Animals chemistry.chemical_classification biology business.industry Glutathione Malondialdehyde Oxidants Rats MicroRNAs Thyroxine Enzyme chemistry 030220 oncology & carcinogenesis Dietary Supplements biology.protein business hormones hormone substitutes and hormone antagonists Oxidative stress |
| Zdroj: | Minerva endocrinology. 46(1) |
| ISSN: | 2724-6116 |
| Popis: | BACKGROUND Hypermetabolic state in hyperthyroidism causes oxidative stress. Erythrocytes are the cells that are involved in oxidant equilibrium in an organism and contain microRNA (miRNA). Selenium, which is an essential element for an organism, has antioxidant properties. The present study was aimed at investigating the effects of selenium supplementation in hyperthyroidism, on pro- and antioxidant enzymes, and miRNA (miR-144 and miR-451) expressions in the erythrocytes. METHODS Forty-eight Sprague-Dawley male rats were divided into 6 groups; control group, group fed with 0.5 mg/kg sodium selenite; group fed with 1 mg/kg sodium selenite; hyperthyroid group; hyperthyroid group fed with 0.5 mg/kg sodium selenite; and hyperthyroid group fed with 1 mg/kg sodium selenite. Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), miR-144, and miR-451 expression levels were studied in erythrocyte hemolysates. RESULTS MDA levels were increased in the hyperthyroid group compared to the control group, and the group fed with 0.5 mg/kg sodium selenite (P |
| Databáze: | OpenAIRE |
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