Dopamine enhances the phosphaturic effect of PTH during acute respiratory alkalosis
| Autor: | Peter D. Kent, Theresa J. Berndt, Gertrude M. Tyce, Franklyn G. Knox, Rochelle R. Tucker, Paul C. Streiff |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Parathyroidectomy medicine.medical_specialty Fractional excretion of sodium Alkalosis Dopamine medicine.medical_treatment Parathyroid hormone Kidney Phosphates Pathology and Forensic Medicine Levodopa Rats Sprague-Dawley Excretion Internal medicine Cyclic AMP medicine Animals Respiratory system Chemistry Drug Synergism General Medicine medicine.disease Rats Endocrinology Parathyroid Hormone Respiratory alkalosis Acute Disease Thyroidectomy Blood Gas Analysis Alkalosis Respiratory Glomerular Filtration Rate medicine.drug |
| Zdroj: | Journal of Laboratory and Clinical Medicine. 134:616-622 |
| ISSN: | 0022-2143 |
| Popis: | The phosphaturic response to parathyroid hormone (PTH) is blunted during acute respiratory alkalosis. The objective of the present study was to determine the effect of dopamine on the blunted phosphaturic response to PTH during acute respiratory alkalosis. The phosphaturic response to PTH was determined in thyroparathyroidectomized (TPTX) normocapnic and respiratory alkalotic rats in the absence and presence of the infusion of exogenous dopamine (25 microg/kg/min) or of 3,4-dihydroxyphenylalanine (L-DOPA, 250 microg/kg/min) to increase endogenous dopamine synthesis. In normocapnic rats, PTH infusion (33 U/kg plus 1 U/kg/min) significantly increased the fractional excretion of phosphate (FE(Pi)), from 1.5%+/-0.5% to 28.4%+/-4.0%, (deltaFE(Pi) 26.9%+/-4.1%, n = 11, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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