Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts
| Autor: | Prabhakar Reddy, Aiming Sun, Xiaoqian Lin, Taylor J. Evers, Terry W. Moore, Dong M. Shin, Nao Morii, Hongzheng Zhang, Alessandra Mancini, Richard F. Arrendale, Zhuo Georgia Chen, Randy B. Howard, Mamoru Shoji, Fadlo R. Khuri, James P. Snyder, Shijun Zhu, Deborah G. Culver, Gabriel Sica, Haian Fu |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Curcumin Angiogenesis Cell Survival Blotting Western Biophysics Cmax Mice Nude Biology Biochemistry Article Metastasis chemistry.chemical_compound Mice Random Allocation Carcinoma medicine Animals Humans Phosphorylation Piperidones Transcription Factor RelA Cancer medicine.disease Head and neck squamous-cell carcinoma Immunohistochemistry Xenograft Model Antitumor Assays Specific Pathogen-Free Organisms Blot chemistry Solubility Head and Neck Neoplasms Immunology Cancer research Carcinoma Squamous Cell Female Signal Transduction |
| Zdroj: | Integrative biology : quantitative biosciences from nano to macro. 4(6) |
| ISSN: | 1757-9708 |
| Popis: | Objectives are to examine the efficacy of new synthetic curcumin analogs EF31 in head and neck squamous cell carcinoma in vitro and in vivo, and study their pharmacokinetic and toxicologic effects in vivo. The synthesis of EF31 was described for the first time. Solubility of EF24, EF31 was compared using nephelometric analysis. Human head and neck squamous cell carcinoma Tu212 xenograft tumors were established in athymic nude mice and treated with EF31 i.p. once daily five days a week for about 5 – 6 weeks. The long term effect of EF31 on the NF-κB signaling system in the tumors was examined by Western blot analysis. EF31 at 25 mg/kg, i.p. inhibited tumor growth almost completely. Solubility of EF24 and EF31 are |
| Databáze: | OpenAIRE |
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