Evaluation of infarcted murine heart function: comparison of prospectively triggered with self-gated MRI
| Autor: | Kees W.A. van de Kolk, Marcel G.J. Nederhoff, Krista den Ouden, Sandra M. Bovens, Cees J. A. van Echteld, Bernard C. M. te Boekhorst, Arno Nauerth, Michiel ten Hove, Gerard Pasterkamp |
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| Přispěvatelé: | Beeldvorming, RS: CARIM School for Cardiovascular Diseases |
| Rok vydání: | 2010 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty Myocardial Infarction retrospective Gating self-gating Electrocardiography Mice Text mining Internal medicine cardiac MRI medicine Animals Radiology Nuclear Medicine and imaging infarct Myocardial infarction mouse Spectroscopy Mice Inbred BALB C Cardiac cycle business.industry Heart medicine.disease Magnetic Resonance Imaging Mice Inbred C57BL medicine.anatomical_structure Ventricle Cardiac hypertrophy cardiovascular system Cardiology Molecular Medicine Acquisition time business |
| Zdroj: | Nmr in Biomedicine, 24(3), 307-315. John Wiley & Sons Inc. |
| ISSN: | 0952-3480 |
| DOI: | 10.1002/nbm.1593 |
| Popis: | Measurement of cardiac function is often performed in mice after, for example, a myocardial infarction. Cardiac MRI is often used because it is noninvasive and provides high temporal and spatial resolution for the left and right ventricle. In animal cardiac MRI, the quality of the required electrocardiogram signal is variable and sometimes deteriorates over time, especially with infarcted hearts or cardiac hypertrophy. Therefore, we compared the self-gated IntraGateFLASH method with a prospectively triggered FLASH (fast low-angle shot) method in mice with myocardial infarcts (n = 16) and in control mice (n = 21). Mice with a myocardial infarct and control mice were imaged in a vertical 9.4-T MR system. Images of contiguous 1-mm slices were acquired from apex to base with prospective and self-gated methods. Data were processed to calculate cardiac function parameters for the left and right ventricle. The signal-to-noise and contrast-to-noise ratios were calculated in mid-ventricular slices. The signal-to-noise and contrast-to-noise ratios of the self-gated data were higher than those of the prospectively gated data. Differences between the two gating methods in the cardiac function parameters for both left and right ventricle (e.g. end-diastolic volumes) did not exceed the inter-observer variability in control or myocardial infarcted mice. Both methods gave comparable results with regard to the cardiac function parameters in both healthy control mice and mice with myocardial infarcts. Moreover, the self-gated method provided better signal-to-noise and contrast-to-noise ratios when the acquisition time was equal. In conclusion, the self-gated method is suitable for routine use in cardiac MRI in mice with myocardial infarcts as well as in control mice, and obviates the need for electrocardiogram triggering and respiratory gating. In both gating methods, more than 10 frames per cardiac cycle are recommended. Copyright © 2010 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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