Postpartum assessment of fetal inflammatory response syndrome in a preterm population with premature rupture of membranes: A Romanian study

Autor:	Alexandru Zaharie, Flaviu Zaharie, Monica Gabriela Hășmășanu, Gabriela Zaharie, Tudor Drugan, Carmen Crivii, Daniel Mureşan, Melinda Matyas
Rok vydání:	2021
Předmět:	Cancer Research medicine.medical_specialty Neonatal intensive care unit Population Prom Sepsis Immunology and Microbiology (miscellaneous) newborn Fraction of inspired oxygen medicine education Survival rate PROM ENA-78 perinatal morbidity education.field_of_study IL-6 Obstetrics business.industry General Medicine Articles medicine.disease TNF-α Necrotizing enterocolitis IL-10 business Premature rupture of membranes
Zdroj:	Experimental and Therapeutic Medicine
ISSN:	1792-1015
Popis:	Fetal inflammatory response syndrome is associated with increased neonatal morbidity and mortality. The aim of the present study was to evaluate the dynamics of the plasmatic value of pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and neutrophil activating peptide 78 (ENA-78) and the anti-inflammatory cytokine IL-10 in the first and third day of life and the correlation with neonatal morbidities and mortality. The current research was designed as a prospective case control study included 80 neonates hospitalized at the 3rd level Neonatal Intensive Care Unit (NICU), 1st Gynecology Clinic, County Emergency Hospital, Cluj-Napoca, Romania. For each patient, the following parameters were noted: pH at first hour of life, oxygen saturation, fraction of inspired oxygen (FiO2) and duration of premature rupture of the membranes (PROM). Measurements of cytokines were determined from venous blood in the first and third day of life. The values of all cytokines were higher in the newborns from mothers with PROM. The value of IL-6 in the study group was higher compared to the controls during the first day of life and met the highest value in necrotizing enterocolitis (NEC). ENA-78 was higher in the study group (P=0.037) and decreased during the first 3 days of life. The highest value of ENA-78 was found in the neonates with cerebral hemorrhage. IL-10 also had values with a significant difference in the first day of life between both groups (P=0.02). IL-10 had the highest value in sepsis cases. In conclusion, among the inflammatory parameters that were evaluated, the dynamics of ENA-78 and IL-10 were found to influence the neonatal prognosis of newborns with PROM. The decrease in ENA-78 and IL-10 during the third day of life could suggest the evolution towards the ending of the inflammatory process and an increase in the survival rate was noted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827badd606f5d455be95f516b5500615 https://pubmed.ncbi.nlm.nih.gov/34707708 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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