Comparison of the performance and clinical utility of a carboxy-terminal assay and an intact assay for parathyroid hormone
| Autor: | William J. Riley, J. Stuart Woodhead, Charmian P. Davies, Ian Weeks, Richard C. Brown, Andrew St John, G. Neil Kent, J.Paul Aston |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
medicine.medical_specialty Hypercalcaemia Clinical Biochemistry Radioimmunoassay Parathyroid hormone Biochemistry law.invention law Internal medicine medicine Humans Chemiluminescence Aged Retrospective Studies Immunoassay Hyperparathyroidism medicine.diagnostic_test business.industry Biochemistry (medical) General Medicine Immunochemiluminometric Assay Middle Aged medicine.disease Endocrinology Parathyroid Hormone Luminescent Measurements Hypercalcemia Kidney Failure Chronic business Primary hyperparathyroidism |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 178(2) |
| ISSN: | 0009-8981 |
| Popis: | A comparison of the performance of a two-site immunochemiluminometric assay for intact parathyroid hormone with that of an in-house radioimmunoassay for carboxy terminal parathyroid hormone has been performed on samples from unselected patients being investigated for hypercalcaemia. The intact parathyroid hormone assay was found to be a simple and robust technique with a broad working assay range (CV less than 10% between 1.8-212 pmol/l) and a detection limit of 0.2 pmol/l. Clinically it is superior to the carboxy terminal assay in its ability to distinguish between patients with hyperparathyroidism from those with other causes of hypercalcaemia especially in the presence of impaired renal function. |
| Databáze: | OpenAIRE |
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