Red blood cell Li+-Na+ countertransport, Na+-K+ cotransport, and the hemodynamics of hypertension
| Autor: | Barbara A. Torretti, Alan L. Hinderliter, M A Fitzpatrick, Alan B. Weder, Stevo Julius, Brent M. Egan |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
medicine.medical_specialty Cardiac output Erythrocytes Sodium-Potassium-Chloride Symporters Diastole Hemodynamics Blood Pressure Lithium Essential hypertension Antiporters Internal medicine Internal Medicine medicine Humans Red Cell business.industry Sodium Middle Aged medicine.disease Red blood cell Blood pressure medicine.anatomical_structure Endocrinology Hypertension Vascular resistance Potassium Vascular Resistance business Carrier Proteins |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 9(5) |
| ISSN: | 0194-911X |
| Popis: | Red blood cell Li+-Na+ countertransport and Na+-K+ cotransport activities, home blood pressure, invasive systemic hemodynamics, and limb venous compliance were measured in 65 white men (23 normotensive, 22 borderline hypertensive, and 20 mild essential hypertensive subjects). Li+-Na+ countertransport activity was positively and significantly correlated with subject-determined home systolic blood pressure (r = 0.31, p less than 0.02) and with directly measured systolic (r = 0.29, p less than 0.02) and diastolic (r = 0.27, p less than 0.03) blood pressures in the hemodynamic laboratory, independent of potential confounding variables. Analysis of the hemodynamic determinants of blood pressure revealed a significant positive correlation of countertransport with vascular resistance (r = 0.30, p less than 0.02) but not with cardiac output or cardiac index. High red blood cell Na+-K+ cotransport activity was not independently associated with hypertension or with a characteristic hemodynamic pattern but was related to decreased venous compliance. Red blood cell Li+-Na+ countertransport deserves further study as a marker for the genetic substrate of human essential hypertension. Red cell Na+-K+ cotransport may be altered secondarily by factors related to high blood pressure and seems to be a valid marker for abnormalities of the venous system in hypertension. |
| Databáze: | OpenAIRE |
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