Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11

Autor:	C. Gary Marshall, Maureen S. Lynes, Collis Alan John, Lili Yao, Kshama Doshi, Pui Yee Ng, Aleksandra Rudnitskaya, Jennifer R. Thomason, Monica A. Alvarez Morales, Xiaozhang Zheng, Matthew W. Martin, Bingsong Han, Jennifer Y. Lee, David R. Lancia, Chiara Conti
Rok vydání:	2018
Předmět:	0301 basic medicine Male Cellular activity Clinical Biochemistry Pharmaceutical Science Mice Nude Isoindoles Biochemistry Histone Deacetylases 03 medical and health sciences chemistry.chemical_compound Mice Structure-Activity Relationship Drug Discovery Animals Humans Enzyme Inhibitors Molecular Biology Mice Inbred BALB C Hydroxamic acid Dose-Response Relationship Drug Molecular Structure HDAC11 Organic Chemistry Isoindoline Recombinant Proteins 030104 developmental biology chemistry Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 28(12)
ISSN:	1464-3405
Popis:	N-Hydroxy-2-arylisoindoline-4-carboxamides are potent and selective inhibitors of HDAC11. The discovery, synthesis, and structure activity relationships of this novel series of inhibitors are reported. An advanced analog (FT895) displays promising cellular activity and pharmacokinetic properties that make it a useful tool to study the biology of HDAC11 and its potential use as a therapeutic target for oncology and inflammation indications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827461c72e8428af478f504b9d6536c3 https://pubmed.ncbi.nlm.nih.gov/29776742 Zobrazit plný text záznamu Full Text from ScienceDirect