203 A longitudinal survey of physical performance and quality of life in adult CF patients

Autor: Markus Hofer, A. Hirt, B. Fiechter Lienert, Annette Boehler, T. Kurowski
Rok vydání: 2013
Předmět:
Zdroj: Journal of Cystic Fibrosis. 12
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(13)60344-6
Popis: Objectives: Radiological imaging plays an important role in the evaluation of pulmonary cystic fibrosis (CF) for the detection of both disease progression and parenchymal lesions. Tomosynthesis (digital tomography) has been recently proposed for pulmonary CF because it has comparatively low radiation dose (0.08– 0.12mSv) and, compared to radiography, it is more sensitive to CF changes, showing them in more details. The purpose of this study is to design and validate a scoring system for tomosyntesis in pulmonary cystic fibrosis of adult patients, comparing with chest radiography, computed tomography (gold standard) and functional parameter (FEV1). Methods: To better investigate strengths and weaknesses of tomosynthesis, we independently scored radiography, tomosynthesis and HRCT examinations of the chest in a group of 20 adult CF patients (23 to 61 years, mean 39 years). Also, we suggested a scoring system to evaluate the whole spectrum of mild to severe pulmonary changes, with well-defined scoring parameters, valid for all radiological investigations. The scoring form provided clear definitions for the severity and extend of five well-recognised pathological changes: overinflation, bronchiectasis, bronchial wall thickening, parenchymal lesions and mucus plugging. Conclusion: We found that correlation between the tomosynthesis and HRCT was high (square-weighted kappa = 0.99) and there was agreement in determining the location and extent of all lesions. We conclude that tomosynthesis is a useful tool in the regular follow-up of CF patients, allowing greater diagnostic accuracy than radiography and lower radiation dose compared with HRCT.
Databáze: OpenAIRE
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