Dual drug release from hydrogels covalently containing polymeric micelles that possess different drug release properties
| Autor: | Yoshihiko Murakami, Tomoki Ito, Ryosuke Anzai, Seiichi Sonotaki, Mari Murata, Taku Takami, Yusuke Uchida |
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| Rok vydání: | 2017 |
| Předmět: |
Drug Liberation
Polyesters macromolecular substances 02 engineering and technology complex mixtures 01 natural sciences Micelle Polyethylene Glycols chemistry.chemical_compound Colloid and Surface Chemistry 0103 physical sciences Rhodamine B Organic chemistry Physical and Theoretical Chemistry Micelles 010304 chemical physics Auramine O Rhodamines technology industry and agriculture Hydrogels Surfaces and Interfaces General Medicine Dynamic mechanical analysis 021001 nanoscience & nanotechnology Polyester Microscopy Fluorescence chemistry Chemical engineering Benzophenoneidum Covalent bond Self-healing hydrogels 0210 nano-technology Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 153:19-26 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2017.02.008 |
| Popis: | In the present study, we designed hydrogels for dual drug release: the hydrogels that covalently contained the polymeric micelles that possess different drug release properties. The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure. Furthermore, we conducted release experiments and fluorescent observations to evaluate the profiles depicting the release of two compounds, rhodamine B and auramine O, from either polymeric micelles or hydrogels. According to our results, (1) hydrogels that covalently contains polymeric micelles that possess different drug release properties successfully exhibit the independent release behaviors of the two compounds and (2) fluorescence microscopy can greatly facilitate efforts to evaluate drug release properties of materials. |
| Databáze: | OpenAIRE |
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