Characterization of DOI, a putative 5-HT2 receptor agonist in the rat
| Autor: | Hubert Dabiré, Cherqui C, Henri Schmitt, Michel Laubie, Kamel Chaouche-Teyara, Berthe Fournier |
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| Rok vydání: | 1989 |
| Předmět: |
Agonist
Male medicine.medical_specialty Serotonin Adrenergic receptor medicine.drug_class Blood Pressure chemistry.chemical_compound Heart Rate Internal medicine medicine Animals Anesthesia Ergolines Receptor 5-HT receptor Pharmacology Dose-Response Relationship Drug 5-HT2 receptor Amphetamines Rats Inbred Strains Receptor antagonist humanities Rats Spiroxatrine Endocrinology chemistry Receptors Serotonin Serotonin Antagonists Idazoxan circulatory and respiratory physiology medicine.drug |
| Zdroj: | European journal of pharmacology. 168(3) |
| ISSN: | 0014-2999 |
| Popis: | DOI (1–100 μg/kg i.v.) induced an increase in mean blood pressure in the anaesthetized rat. Similarly, in the pithed rat, DOI (1–100 μg/kg i.v.) induced a dose-dependent increase in mean blood pressure, as did 5-HT. However, in contrast to 5-HT, DOI did not change the heart rate in either intact or pithed rats. In the pithed rat, the dose-pressor response curves to both 5-HT and DOI were unaffected by MDL 72222 (5-HT 3 receptor antagonist), spiroxatrine or (±)-pindolol) (5-HT 1A receptor antagonists), idazoxan ( α 2 -adrenoceptor blocking agent) and AR-C 239 ( α 1 -adrenoceptor blocking agent). Only the selective 5-HT 2 receptor antagonist, LY 53857, significantly and dose dependently shifted to the right the dose-response curves to both 5-HT and DOI. These results indicated that DOI possesses 5-HT 2 agonistic properties and that the pressor response induced by DOI in the pithed rat is mediated via 5-HT 2 receptors. |
| Databáze: | OpenAIRE |
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