HLA class II genetic diversity in southern Tunisia and the Mediterranean area
| Autor: | B. Yacoubi Loueslati, A. Dridi, B. Abdennaji Guenounou, Houssein Khodjet-El-Khil, Hajer Ennafaa, A. Ben Ammar Elgaaied, N. Moojat, Slama Hmida, Stéphane Buhler, K. Boukef, Alicia Sanchez-Mazas |
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| Rok vydání: | 2006 |
| Předmět: |
Hla class ii
Mediterranean climate Tunisia Immunology HLA-DQ Antigens/genetics Gene Frequency HLA-DQ Antigens Genetics HLA-DQ beta-Chains Humans Colonization Allele Molecular Biology Genetics (clinical) Alleles ddc:599.9 Genetic diversity Middle East Ecology Mediterranean Region HLA-DR Antigens/genetics Haplotype Genetic Variation General Medicine HLA-DR Antigens Geography Genetics Population Haplotypes Mediterranean area Population Genetics HLA-DRB1 Chains |
| Zdroj: | International Journal of Immunogenetics, Vol. 33, No 2 (2006) pp. 93-103 |
| ISSN: | 1744-3121 |
| Popis: | North Africa is populated by many Arab- and Berber-speaking populations whose genetic history is still poorly understood. In this study, we analyse the HLA-DRB1 and DQB1 molecular diversity in three populations from the south of Tunisia--Berbers from Jerba, Berbers from Matmata and Arabs from Gabes--and we compare them to a large set of populations from the whole Mediterranean region. Among the three populations studied, the Berbers from Jerba are the most peculiar, as they diverge significantly from other North Africans while being genetically highly diversified and close to populations from the Near East. Thus, Jerba may have been a crossing point, in historical times, where colonization from the eastern Mediterranean area left significant genetic traces. By contrast, the populations from Matmata and Gabes are genetically similar to other Arab and Berber-speaking populations from different areas of the Maghrib, despite some peculiar allele and haplotype frequencies. At a larger scale, northwest Africa and southwest Europe are closely related according to these polymorphisms, while the populations from the eastern Mediterranean area are much more differentiated. The close genetic relatedness found for HLA among populations of the western Mediterranean region challenges previous results based on Y chromosome analyses, where the Gibraltar Strait appeared to constitute a main genetic barrier. |
| Databáze: | OpenAIRE |
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