Genetic analysis of cleft lip with or without cleft palate in Madras, India
| Autor: | Mary L. Marazita, Michael Melnick, Lakshmi J. Nemana |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Proband Genetics education.field_of_study Models Genetic Cleft Lip Population Infant Newborn India Locus (genetics) Complex segregation analysis Biology Genetic analysis Cleft Palate Risk Factors Genetic etiology Humans Population study Female Sex Ratio Facial development education Genetics (clinical) |
| Zdroj: | American Journal of Medical Genetics. 42:5-9 |
| ISSN: | 1096-8628 0148-7299 |
| DOI: | 10.1002/ajmg.1320420103 |
| Popis: | We performed a genetic analysis of 331 non-syndromic cleft lip with or without cleft palate (CL +/- P) proband families ascertained in Madras, India. Predictions of the multifactorial threshold (MF/T) model are tested; goodness-of-fit tests of the MF/T model and complex segregation analysis are also utilized to clarify the genetic etiology of CL +/- P in this study population. There was little evidence for the MF/T model. The most reasonable conclusion from mixed model analysis is that of a major locus with reduced transmission probability. This is not altogether surprising if manifestation of CL +/- P also depends on in utero exposure to harmful environmental agents during the critical period of facial development, as suggested by Melnick et al. [1980] and demonstrated in an animal model of CL +/- P [Melnick et al., 1981]. Further the results in the Madras population are quite similar to those in other populations of Europe and Asia. |
| Databáze: | OpenAIRE |
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