Clinical and cardiovascular alterations produced by scorpion envenomation in dogs

Autor: Michiko Sakate, P. R. Cuyumjian, V. Fernandes, F. F. Cordeiro
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Zdroj: Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 12, Issue: 1, Pages: 19-43, Published: 2006
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 1, Pp 19-43 (2006)
Journal of Venomous Animals and Toxins including Tropical Diseases v.12 n.1 2006
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Scopus
Repositório Institucional da UNESP
Popis: Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:21:51Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:45:38Z : No. of bitstreams: 1 2-s2.0-33645888428.pdf: 546909 bytes, checksum: c1c043e9d62b74a3ff65a363b3b1b143 (MD5) Made available in DSpace on 2014-05-27T11:21:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-04-26 Scorpionism is a common problem that occurs in tropical and subtropical countries and assumes great medical-sanitary importance due to its fatal effect on sensitive individuals, being able to lead children and aged people to death. The envenomation lethal potential is responsible for the serious cardiopulmonary alterations the scorpion toxin produces in its victims. The present research evaluated the effects of Tityus serrulatus venom on dogs, using two distinct doses: a dose that simulates natural envenomation (0.4 mg/total dose), and an experimental dose (0.25 mg/kg). General clinical signs were observed at different moments after envenomation, and specific data related to the cardiopulmonary system were evaluated by systemic arterial pressure measurement, CK-MB enzymatic activity dosage, and radiographic, electrocardiographic and echocardiographic examinations. Results demonstrated that the scorpion venom, in experimental doses, was able to cause acute and reversible cardiac injury in few days, and, in the dose that simulated natural accident, it produced clinical signs of light envenomation, such as local pain, hyperesthesia, sialorrhea, vomiting, diarrhea, sneeze and prostration. Department of Clinical Veterinary Medicine School of Veterinary Medicine and Animal Husbandry São Paulo State University, Botucatu, São Paulo Clinical Laboratory School of Veterinary Medicine and Animal Husbandry São Paulo State University, Botucatu, São Paulo Veterinary Diagnostic, São Paulo Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia UNESP, Distrito de Rubião Jr., s/n, 18.618-000, Botucatu, SP Department of Clinical Veterinary Medicine School of Veterinary Medicine and Animal Husbandry São Paulo State University, Botucatu, São Paulo Clinical Laboratory School of Veterinary Medicine and Animal Husbandry São Paulo State University, Botucatu, São Paulo Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia UNESP, Distrito de Rubião Jr., s/n, 18.618-000, Botucatu, SP
Databáze: OpenAIRE