Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury

Autor: Susan Murray, Sarah M Moran, Derek G. Doherty, Eóin C O'Brien, Alan Kennedy, Ana Moreno-Olivera, Mark A. Little, Barbara Fazekas, Dearbhaile Dooley, Jennifer Scott, Niall Conlon, Yvelynne Kelly, Ashanty M. Melo, Paul V. O’Hara, Fionnuala B. Hickey
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
Pathology
medicine.medical_specialty
Cell type
viruses
T-Lymphocytes
Lymphocyte
Immunology
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Mucosal associated invariant T cell
Kidney
Mucosal-Associated Invariant T Cells
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Eosinophilic
medicine
Humans
Immunology and Allergy
Lymphocyte Count
B cell
Aged
Aged
80 and over
Immunosuppression Therapy
B-Lymphocytes
Innate immune system
business.industry
Microcirculation
Innate lymphoid cell
Receptors
Antigen
T-Cell
gamma-delta
Original Articles
Middle Aged
medicine.disease
Immunity
Innate
Lymphocyte Subsets
030104 developmental biology
medicine.anatomical_structure
Natural Killer T-Cells
Female
business
Granulomatosis with polyangiitis
030215 immunology
Zdroj: Clinical and Experimental Immunology. 191:180-188
ISSN: 1365-2249
0009-9104
DOI: 10.1111/cei.13058
Popis: Summary Innate lymphocyte populations, such as innate lymphoid cells (ILCs), γδ T cells, invariant natural killer T (iNK T) cells and mucosal-associated invariant T (MAIT) cells are emerging as important effectors of innate immunity and are involved in various inflammatory and autoimmune diseases. The aim of this study was to assess the frequencies and absolute numbers of innate lymphocytes as well as conventional lymphocytes and monocytes in peripheral blood from a cohort of anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV) patients. Thirty-eight AAV patients and 24 healthy and disease controls were included in the study. Patients with AAV were sampled both with and without immunosuppressive treatment, and in the setting of both active disease and remission. The frequencies of MAIT and ILC2 cells were significantly lower in patients with AAV and in the disease control group compared to healthy controls. These reductions in the AAV patients remained during remission. B cell count and frequencies were significantly lower in AAV in remission compared to patients with active disease and disease controls. Despite the strong T helper type 2 (Th) preponderance of eosinophilic granulomatosis with polyangiitis, we did not observe increased ILC2 frequency in this cohort of patients. The frequencies of other cell types were similar in all groups studied. Reductions in circulating ILC2 and MAIT cells reported previously in patients with AAV are not specific for AAV, but are more likely to be due to non-specific manifestations of renal impairment and chronic illness. Reduction in B cell numbers in AAV patients experiencing remission is probably therapy-related.
Databáze: OpenAIRE
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