Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma
| Autor: | Takahisa Yamashita, Michihide Tokuhira, Keiko Abe, Morihiro Higashi, Satoshi Fujino, Eiichi Arai, Jun-ichi Tamaru, Masahiro Kizaki |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Cancer Research Adolescent Population Gene Expression Immunophenotyping 03 medical and health sciences Young Adult 0302 clinical medicine hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine HLA-DR Tumor Microenvironment Humans IL-2 receptor education Aged Neoplasm Staging Aged 80 and over education.field_of_study Tumor microenvironment business.industry Hematology HLA-DR Antigens Middle Aged medicine.disease Prognosis Survival Analysis Lymphoma Immunosurveillance Phenotype Oncology 030220 oncology & carcinogenesis Immunology Cancer research Female Lymphoma Large B-Cell Diffuse Neoplasm Grading business Diffuse large B-cell lymphoma CD8 Biomarkers 030215 immunology |
| Zdroj: | Leukemialymphoma. 57(1) |
| ISSN: | 1029-2403 |
| Popis: | The interaction between tumor cells and the tumor microenvironment is essential in the development and progression of diffuse large B-cell lymphoma (DLBCL). Loss of human leukocyte antigen DR (HLA-DR) in DLBCL is a robust adverse prognostic marker. We evaluated the immunohitochemical expression of HLA-DR in lymphoma and the biologic implications of the loss of HLA-DR. The loss of HLA-DR correlated with clinical stage (p < 0.05), International Prognosis Index (p < 0.05), soluble interleukin-2 receptor (p < 0.05) and poor outcome in patients with DLBCL, especially among elderly patients. Flow cytometry analysis of the infiltrating T-cells showed that the mean CD4 + CD25 +/CD8 ratio of the infiltrating T-cells was higher in the HLA-DR positive group than in the HLA-DR negative group (p < 0.05). These data suggest that loss of HLA-DR expression in DLBCL decreases the ratio of helper T-cell within the T-cell population in the tumor microenvironment and might contribute to escape from immunosurveillance. |
| Databáze: | OpenAIRE |
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