Strain-induced crack formations in PDMS/DXA drug collars
| Autor: | Chris Frethem, S. Meyer, J. Gonerka, Jacob A. Warner, J.C. Polkinghorne, Bing Luo, Greg Haugstad |
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| Rok vydání: | 2013 |
| Předmět: |
Drug
Materials science Compressive Strength Surface Properties Scanning electron microscope media_common.quotation_subject Biomedical Engineering Nanotechnology Biochemistry Dexamethasone Collar Diffusion Biomaterials chemistry.chemical_compound Hardness Elastic Modulus Tensile Strength Materials Testing Microscopy Dimethylpolysiloxanes Composite material Molecular Biology media_common Polydimethylsiloxane Strain (chemistry) Atomic force microscopy Drug-Eluting Stents General Medicine Electrodes Implanted Nylons chemistry Drug delivery Stress Mechanical Biotechnology |
| Zdroj: | Acta Biomaterialia. 9:7335-7342 |
| ISSN: | 1742-7061 |
| DOI: | 10.1016/j.actbio.2013.03.028 |
| Popis: | Drug-eluting systems are currently used in cardiac leads in order to reduce inflammation and fibrosis at the lead–tissue interface. Drug release from these drug delivery systems can be modulated by the manufacturing processes used to create the drug systems and assemble them onto the cardiac lead. In this study, scanning electron microscopy, atomic force microscopy and Raman microscopy are employed to explore the material characteristics of a polydimethylsiloxane–dexamethasone acetate drug collar used on cardiac leads when varying the strain during collar assembly on the lead. A novel test fixture was created in order to investigate these drug collars under simulated stresses. Measurements of the collar while fitted to a rod revealed microcracks that are hypothesized to affect the drug release performance, resulting in increased drug elution. It was found that the strain that occurs during assembly of the collar onto the lead is a key factor in the formation of these microcracks. Results also suggest that cracks tend to form in areas of high drug particle density, and propagate between drug particles. |
| Databáze: | OpenAIRE |
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