Successful Long-Term Outcomes Using Pediatric En Bloc Kidneys for Transplantation
| Autor: | Chris E. Freise, Henry R. Randall, Peter N. Bretan, Jade S. Hiramoto, Peter G. Stock, Ryutaro Hirose, Stephen J. Tomlanovich |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Azathioprine chemistry.chemical_compound medicine Humans Immunology and Allergy Pharmacology (medical) Kidney transplantation Sex Characteristics Transplantation Kidney Creatinine business.industry Body Weight Graft Survival Racial Groups Age Factors Infant Immunosuppression Organ Size medicine.disease Kidney Transplantation Tacrolimus Surgery Regimen surgical procedures operative medicine.anatomical_structure chemistry Child Preschool Female Transplantation Tolerance business Follow-Up Studies medicine.drug |
| Zdroj: | American Journal of Transplantation. 2:337-342 |
| ISSN: | 1600-6135 |
| DOI: | 10.1034/j.1600-6143.2002.20408.x |
| Popis: | Goal: The objective of our study was to determine whether acceptable long-term graft survival and function can be achieved using pediatric en bloc renal transplants by employing specific immunologic and selection strategies. Materials and Methods: A retrospective analysis of pediatric en bloc kidney transplants at a single institution was performed. A Kaplan-Meier analysis was used to evaluate graft survival. Findings: Fifty-seven adult recipients with at least a 1-year follow-up period were successfully transplanted using pediatric en bloc kidneys between 1993 and 1998. Complete data regarding immunosuppression were available for 53 patients. All patients had a cyclosporine (CsA)- or tacrolimus (TAC)-based regimen with either azathioprine (Aza) or mycophenolate mofetil (MMF) and corticosteroids. All but two received induction with OKT3. One-, 3-, 4-, 5- and 7-year graft survival was calculated to be 88%, 86%, 83%, 68% and 68%, respectively. The mean serum creatinine value at 3 years was 1.0 ± 0.4 mg/dL. Thirteen patients (23%) had biopsy-proven rejection. Ten of 19 (53%) patients treated with CsA/Aza had rejection, whereas 2/15 (13%) on CsA/MMF and 1/19 (5%) of patients on TAC/MMF had rejection. Nine patients (16%) had surgical complications. Conclusion: Excellent long-term results can be achieved in pediatric en bloc kidney transplantation using OKT3, TAC and MMF in carefully selected adult recipients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text