Go-sha-jinki-Gan (GJG), a traditional Japanese herbal medicine, protects against sarcopenia in senescence-accelerated mice
| Autor: | Yuki Kishida, Hideki Yoshikawa, Shizue Otsuka, Keisuke Hagihara, Junsuke Arimitsu, Miho Nakanishi, Noriko Sakashita, Syota Kagawa |
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| Rok vydání: | 2015 |
| Předmět: |
Senescence
Male medicine.medical_specialty Aging Sarcopenia Ubiquitin-Protein Ligases Muscle Fibers Skeletal Muscle Proteins Pharmaceutical Science Cell Cycle Proteins AMP-Activated Protein Kinases Tripartite Motif Proteins Glycogen Synthase Kinase 3 Mice Internal medicine Drug Discovery medicine Animals Muscle Strength Go-sha-jinki-Gan (GJG) Insulin-Like Growth Factor I Phosphorylation Muscle Skeletal Protein kinase B Pharmacology Glycogen Synthase Kinase 3 beta business.industry Therapeutic effect AMPK Forkhead Transcription Factors Senescence-accelerated mice (SAMP8) medicine.disease Blot Muscular Atrophy Endocrinology Complementary and alternative medicine FOXO4 Molecular Medicine business Proto-Oncogene Proteins c-akt Drugs Chinese Herbal |
| Zdroj: | Phytomedicine. 22(1):16-22 |
| ISSN: | 0944-7113 |
| DOI: | 10.1016/j.phymed.2014.11.005 |
| Popis: | Sarcopenia is characterized by age-associated skeletal muscle atrophy and reduced muscle strength; currently, no pharmaceutical treatment is available. Go-sha-jinki-Gan (GJG) is a traditional Japanese herbal medicine that is used to alleviate various age-related symptoms, especially motor disorders. Here, we investigated the effect of GJG on aging-associated skeletal muscle atrophy by using senescence-accelerated mice (SAMP8). Immunohistochemical and western blotting analyses clearly showed that GJG significantly reduced the loss of skeletal muscle mass and ameliorated the increase in slow skeletal muscle fibers in SAMP8 mice compared to control mice. The expression levels of Akt and GSK-3β, the phosphorylation of FoxO4, and the phosphorylations of AMPK and mitochondrial-related transcription factors such as PGC-1α were suppressed, while the expression of MuRF1 increased in SAMP8 mice, but approximated that in senescence-accelerated aging-resistant (SAMR1) mice after GJG treatment. We demonstrate for the first time that GJG has a therapeutic effect against sarcopenia. |
| Databáze: | OpenAIRE |
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