Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E

Autor: Laurent Alric, Nassim Kamar, Jean-Pierre Vinel, Jacques Izopet, Christophe Bureau, Pascal Cintas, René Gerolami, Jean-Marie Péron, H. Blasco Perrin, Louis d’Alteroche, J.-N. Raynal, P. Couzigou, J.-M. Liversain, L. Prudhomme, E. Vaucher, Florence Abravanel, Emmanuel Dupuis
Přispěvatelé: Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Marseille, CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Clinique de l'union, Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Clinique Pasteur, Clinique Pasteur [Toulouse], Centre Hospitalier Intercommunal Castres-Mazamet (CHIC-CM), Centre Hospitalier de Narbonne, CHU Bordeaux [Bordeaux], Intensive Care Unit, Centre Hospitalier de Mont De Marsan, 40000, Mont-de-Marsan, CHU Toulouse [Toulouse], Clinique de l'Union, Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Parsonage–Turner syndrome
Pediatrics
Epidemiology
[SDV]Life Sciences [q-bio]
viruses
lcsh:Medicine
medicine.disease_cause
chemistry.chemical_compound
Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E
Hepatitis E virus
Autochthonous Acute Hepatitis E
Suggested citation for this article: Blasco Perrin H
d’Alteroche L
Immunocompetent Patients
Guillain-Barre syndrome
biology
Mononeuritis Multiplex
virus diseases
Middle Aged
Guillain-Barré syndrome
Hepatitis E
demyelinating neuropathy
3. Good health
Infectious Diseases
Acute Disease
Synopsis
Education
Medical
Continuing
Female
Immunocompetence
Antibody
Adult
Microbiology (medical)
medicine.medical_specialty
Abravanel F
et al. Neurologic disorders in nonimmunocompromised patients with autochthonous acute hepatitis E. Emerg Infect Dis. 2015 Nov [date cited]. http://dx.doi.org/10.3201/eid2111.141789
meningoradiculitis
hepatitis E virus
Raynal JN
mononeuritis multiplex
lcsh:Infectious and parasitic diseases
medicine
Humans
Gérolami R
lcsh:RC109-216
Aged
Cintas P
business.industry
Ribavirin
lcsh:R
medicine.disease
immunocompetent
digestive system diseases
chemistry
neurological manifestations
HEV
Immunology
biology.protein
hepatitis E
Nervous System Diseases
business
neurologic disorders
Zdroj: Emerging Infectious Diseases, Vol 21, Iss 11, Pp 1928-1934 (2015)
Emerging Infectious Diseases
Emerging Infectious Diseases, 2015, 21 (11), ⟨10.3201/eid2111.141789⟩
Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2015, 21 (11), ⟨10.3201/eid2111.141789⟩
ISSN: 1080-6040
1080-6059
Popis: Patients with acute neurologic manifestations and aminotransferase abnormalities should be screened for hepatitis E virus infection.
Neurologic disorders, mainly Guillain-Barré syndrome and Parsonage–Turner syndrome (PTS), have been described in patients with hepatitis E virus (HEV) infection in industrialized and developing countries. We report a wider range of neurologic disorders in nonimmunocompromised patients with acute HEV infection. Data from 15 French immunocompetent patients with acute HEV infection and neurologic disorders were retrospectively recorded from January 2006 through June 2013. The disorders could be divided into 4 main entities: mononeuritis multiplex, PTS, meningoradiculitis, and acute demyelinating neuropathy. HEV infection was treated with ribavirin in 3 patients (for PTS or mononeuritis multiplex). One patient was treated with corticosteroids (for mononeuropathy multiplex), and 5 others received intravenous immunoglobulin (for PTS, meningoradiculitis, Guillain-Barré syndrome, or Miller Fisher syndrome). We conclude that pleiotropic neurologic disorders are seen in HEV-infected immunocompetent patients. Patients with acute neurologic manifestations and aminotransferase abnormalities should be screened for HEV infection.
Databáze: OpenAIRE
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