Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
| Autor: | R G Quo, Ross M Okamura, Rudolf Grosschedl, Isabel Fariñas, C van Genderen, L Bruhn, Tristram G. Parslow |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
animal structures
Lymphoid Enhancer-Binding Factor 1 Mutant Biology Epithelium Mesoderm Embryonic and Fetal Development Mice Mammary Glands Animal Genetics Animals Trigeminal Nerve Germ-Line Mutation Trigeminal nerve Embryonic Induction Embryogenesis Mesenchymal stem cell Neural crest Mice Mutant Strains Cell biology Enamel knot DNA-Binding Proteins Hair follicle morphogenesis Neural Crest embryonic structures Immunology Genes Lethal Tooth Developmental Biology Lymphoid enhancer-binding factor 1 Hair Transcription Factors |
| Zdroj: | Genesdevelopment. 8(22) |
| ISSN: | 0890-9369 |
| Popis: | Lymphoid enhancer factor 1 (LEF-1) is a sequence-specific DNA-binding protein that is expressed in pre-B and T lymphocytes of adult mice, and in the neural crest, mesencephalon, tooth germs, whisker follicles, and other sites during embryogenesis. We have generated mice carrying a homozygous germ-line mutation in the LEF-1 gene that eliminates its protein expression and causes postnatal lethality. The mutant mice lack teeth, mammary glands, whiskers, and hair but show no obvious defects in lymphoid cell populations at birth. The LEF-1-deficient mice also lack the mesencephalic nucleus of the trigeminal nerve, the only neural crest-derived neuronal populations. Together, the pattern of these defects suggest an essential role for LEF-1 in the formation of several organs and structures that require inductive tissue interactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|