Butterfly wing pattern evolution is associated with changes in a Notch/Distal-less temporal pattern formation process
| Autor: | Robert D. Reed, Michael S Serfas |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
0106 biological sciences
animal structures Lineage (genetic) Time Factors Mutant Pattern formation Biology 010603 evolutionary biology 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Animals Wings Animal Transcription factor 030304 developmental biology Body Patterning Homeodomain Proteins 0303 health sciences Wing Phylogenetic tree Agricultural and Biological Sciences(all) Receptors Notch Biochemistry Genetics and Molecular Biology(all) Pigmentation Gene Expression Regulation Developmental Membrane Proteins Anatomy Phenotype Biological Evolution Immunohistochemistry Evolutionary biology Eyespot General Agricultural and Biological Sciences Butterflies Transcription Factors |
| Zdroj: | Current biology : CB. 14(13) |
| ISSN: | 0960-9822 |
| Popis: | In butterflies there is a class of "intervein" wing patterns that have lines of symmetry halfway between wing veins. These patterns occur in a range of shapes, including eyespots, ellipses, and midlines, and were proposed to have evolved through developmental shifts along a midline-to-eyespot continuum. Here we show that Notch (N) upregulation, followed by activation of the transcription factor Distal-less (Dll), is an early event in the development of eyespot and intervein midline patterns across multiple species of butterflies. A relationship between eyespot phenotype and N and Dll expression is demonstrated in a loss-of-eyespot mutant in which N and Dll expression is reduced at missing eyespot sites. A phylogenetic comparison of expression time series from eight moth and butterfly species suggests that intervein N and Dll patterns are a derived characteristic of the butterfly lineage. Furthermore, prior to eyespot determination in eyespot-bearing butterflies, N and Dll are transiently expressed in a pattern that resembles ancestral intervein midline patterns. In this study we establish N upregulation as the earliest known event in eyespot determination, demonstrate gene expression associated with intervein midline color patterns, and provide molecular evidence that wing patterns evolved through addition to and truncation of a conserved midline-to-eyespot pattern formation sequence. |
| Databáze: | OpenAIRE |
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