Locally advanced breast cancer: report of phase II study and subsequent phase III trial
| Autor: | G.R. Kerr, Wilma Jack, P. D. J. Hardman, Udi Chetty, A. Rodger, R. C. F. Leonard |
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| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Vincristine Cyclophosphamide medicine.medical_treatment Phases of clinical research Breast Neoplasms CHOP law.invention Breast cancer Randomized controlled trial law Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Prospective Studies Aged Chemotherapy Clinical Trials as Topic Radiotherapy business.industry Middle Aged medicine.disease Combined Modality Therapy Surgery Radiation therapy Doxorubicin Drug Evaluation Prednisone Female business medicine.drug Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Twenty-four evaluable patients with stage T4 breast cancer were entered into a phase II study and received chemotherapy comprising cyclophosphamide 1,000 mg m-2 i.v., doxorubicin 50 mg m-2 i.v., vincristine 1.4 mg m-2 i.v. and prednisolone 40 mg orally for 5 days, given 3 weekly for four cycles prior to undergoing loco-regional radiotherapy. All patients completed treatment as planned with no major acute toxicity from either chemotherapy or radiotherapy. Subsequently 52 patients with stage T4 breast cancer were randomised in a phase III trial to receive either radiotherapy alone (RT) or this chemotherapy and radiotherapy (CHOP + RT). A significantly higher complete response rate was achieved in the CHOP + RT treatment arm (P = 0.03). However a larger proportion of the RT arm achieved loco-regional control after salvage treatment for relapse such that 50% of the RT arm and 57% of the CHOP + RT arm had no evidence of loco-regional disease at the time of last follow-up or death. There was no statistical difference in time to distant relapse or overall survival. Analysis of the pilot study showed results comparable to the trial CHOP + RT arm. This trial suggests that this cytotoxic therapy used in conjunction with radiotherapy has only marginal value in improving prognosis in locally advanced breast cancer. |
| Databáze: | OpenAIRE |
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