Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–20111
| Autor: | Gary V. Doern, Sandra S. Richter, Kristopher P. Heilmann, Fathollah Riahi, Daniel J. Diekema, Cassie L. Dohrn |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Serotype Pneumococcal serotypes Epidemiology Biology medicine.disease_cause Pneumococcal conjugate vaccine Microbiology conjugate vaccines vaccine Streptococcus pneumoniae medicine serotype bacteria Research pathogenesis medicine.disease Virology United States Pneumococcal infections Infectious Diseases Pneumococcal vaccine streptococci Penicillin resistance Conjugate medicine.drug |
| Zdroj: | Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Serotyping data for pneumococci causing invasive and noninvasive disease in 2008-2009 and 2010-2011 from >43 US centers were compared with data from preconjugate vaccine (1999-2000) and postconjugate vaccine (2004-2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decreased from 64% of invasive and 50% of noninvasive isolates in 1999-2000 to 3.8% and 4.2%, respectively, in 2010-2011. Increases in serotype 19A stopped after introduction of 13-valent pneumococcal vaccine (PCV13) in 2010. Prevalences of other predominant serotypes included in or related to PCV13 (3, 6C, 7F) also remained similar for 2008-2009 and 2010-2011. The only major serotype that increased from 2008-2009 to 2010-2011 was nonvaccine serotype 35B. These data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease. |
| Databáze: | OpenAIRE |
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