Clinical investigation of the biological effects of a new combination low-dose oral contraceptive (‘Ovostat E’)
| Autor: | S. Hulkko, Alapiessa U, Kauraniemi T, T. Tarkkila |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
medicine.medical_specialty Biopsy media_common.quotation_subject Urinary system Ethinyl Estradiol Lynestrenol Endometrium chemistry.chemical_compound Liver Function Tests Internal medicine Humans Endocrine system Medicine Ovulation Progesterone media_common Vaginal Smears Estradiol business.industry Estrogens General Medicine Luteinizing Hormone medicine.disease Hypoplasia Contraceptives Oral Combined Clinical research Endocrinology chemistry Pregnanediol Female business Luteinizing hormone Contraceptives Oral Sequential medicine.drug |
| Zdroj: | Current Medical Research and Opinion. 5:247-251 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007997709110173 |
| Popis: | A low-dose contraceptive containing 1 mg of lynestrenol and .05 mg of ethinyl estradiol was studied over 12 cycles in 11 healthy fertile women volunteers. The subjects were aged 20-30 years. Measurements were taken of urinary luteinizing hormone (LH), pregnanediol, and estrogen, and serum progesterone and estradiol values; in addition, on a fixed schedule during treatment, the 3rd, 5th, 7th, and 12th months, vaginal smears and endometrial biopsies were taken, along with SGOT and SGPT determinations. According to determinations, ovulation was inhibited during every cycle tested. A clear estrogenic effect was evident in the karyopyknotic index, during cycle 3, at the beginning of the cycle which became a progestational effect around Day 13 (biphasic). In cycle 6, the indexes of cytology decreased, but during Cycle 12, they rose a bit again. Basal body temperature during treatment was monophasic. Cervical mucus assessed by spinnbarket during treatment was low and arborization absent. The SGOT and SGPT liver function tests were within normal values in all cycles in 7 women; 4 showed clearly higher levels in Cycles 3 and 12. None of the cycles showed the high midcycle urinary excretion of LH. No significant side effects were reported. Examination of the endometrial biopsies showed a drug effect in all cases and there was no secretory activity in any of the samples. These findings confirm clinical results that show this low-dose combination to be an effective contraceptive agent. |
| Databáze: | OpenAIRE |
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