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Background:. Motor activity of the colon during sleep is relatively quiescent but bursts of activity are observed during periods of arousal and when sleep is completed. However, it is not known how sleep alters the colonic motility of parsons with SCI. We thus studied the effect of sleep on the colonic motility of subjects with SCI and compared it with that in persons who were spinally intact (SI). Method£ The study was conducted on 8 subjects with SCI (mean age of 59 years, mean duration of injury of 17 years, 4 paraplegics, 4 quadriplegies), and 6 SI subjects (mean age 57 years). SCI subjects all complained of difficulty with evacuation (DWE) at least once in 6 months preceding the study; all received bowel care at least three/ week. After routine bowel preparation with lavage solution or Phosphosoda, colonoscopy was performed (all subjects had normal examinations). After colonoacopy, the proximal end of a solid-state pressure transducer catheter (4 sensors each separated by 10 cme.) was tethered to the splenic flexure using endoclips (Olympus Corp.) The subjects ware then allowed to carry out their usual daily activities, including sleep. Data from the catheter was recorded on a Gaeltec portable recorder. After compl~on of the study (which lasted 24 hours), the data was uploaded to a desktop computer for analysis. Significance of the difference between groups was evaluated by Student's T-test. Result. During sleep, the motility index was significantly lower in subjects with SCI than the SI (1.5 vs. 5.8, p |
