Correlation analysis of levels of inflammatory cytokines and nitric oxide in peripheral blood with urine proteins and renal function in patients with gestational hypertension
| Autor: | Xiao-Xiao Cao, Hong-Xia Wen, Hong-Yan Zhang, Jing-Yang Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Gestational hypertension
Cancer Research medicine.medical_specialty inflammatory cytokine nitric oxide urine protein Homocysteine Renal function 030209 endocrinology & metabolism Urine Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine hypertensive disorder complicating pregnancy Immunology and Microbiology (miscellaneous) Internal medicine medicine 030212 general & internal medicine Pregnancy Creatinine business.industry renal function Gestational age General Medicine Articles medicine.disease Blood pressure chemistry business |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | The aim of the study was to investigate correlations among inflammatory cytokines, nitric oxide (NO) level, urine protein, renal function and blood pressure in peripheral blood of patients with hypertensive disorder complicating pregnancy (HDCP). A total of 60 patients diagnosed with HDCP in the Obstetrics Department of Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology from May 2016 to April 2017 were selected. The patients were divided into the HDCP (n=20), mild pre-eclampsia (n=20) and severe pre-eclampsia (n=20) groups. Additionally, 20 healthy pregnant women were selected as the control group. General data of the patients were collected. NO, renal function and 24-h urine protein were measured. The systolic and diastolic blood pressure, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the HDCP group was significantly higher than that in the control group. The CRP, TNF-α and IL-6 levels in the pre-eclampsia groups were higher than those in the gestational hypertension group (P |
| Databáze: | OpenAIRE |
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