Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction
| Autor: | Cara L. Green, Heidi H. Pak, Nicole E. Richardson, Victoria Flores, Deyang Yu, Jay L. Tomasiewicz, Sabrina N. Dumas, Katherine Kredell, Jesse W. Fan, Charlie Kirsh, Krittisak Chaiyakul, Michaela E. Murphy, Reji Babygirija, Gregory A. Barrett-Wilt, Joshua Rabinowitz, Irene M. Ong, Cholsoon Jang, Judith Simcox, Dudley W. Lamming |
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| Rok vydání: | 2022 |
| Předmět: |
Male
precision dietetics Physiology 1.1 Normal biological development and functioning Protein-Restricted Medical Biochemistry and Metabolomics UM-HET3 liver Article Endocrinology & Metabolism Mice FGF21 Underpinning research Genetics Diet Protein-Restricted 2.2 Factors relating to the physical environment Animals protein restriction Obesity Aetiology Molecular Biology Metabolic and endocrine Nutrition metabolic health Prevention Diabetes Cell Biology multi-omics Diet Fibroblast Growth Factors Good Health and Well Being Liver sexual dimorphism genetic variation Female Biochemistry and Cell Biology Insulin Resistance Energy Metabolism Genetic Background |
| Zdroj: | Cell Metab Cell metabolism, vol 34, iss 2 |
| ISSN: | 1550-4131 |
| Popis: | Low-protein diets promote metabolic health in humans and rodents. Despite evidence that sex and genetic background are key factors in the response to diet, most protein intake studies examine only a single strain and sex of mice. Using multiple strains and both sexes of mice, we find that improvements in metabolic health in response to reduced dietary protein strongly depend on sex and strain. While some phenotypes were conserved across strains and sexes, including increased glucose tolerance and energy expenditure, we observed high variability in adiposity, insulin sensitivity, and circulating hormones. Using a multi-omics approach, we identified mega-clusters of differentially expressed hepatic genes, metabolites, and lipids associated with each phenotype, providing molecular insight into the differential response to protein restriction. Our results highlight the importance of sex and genetic background in the response to dietary protein level, and the potential importance of a personalized medicine approach to dietary interventions. |
| Databáze: | OpenAIRE |
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