Genome Sequences of Akhmeta Virus, an Early Divergent Old World Orthopoxvirus
Autor: | Darin S. Carroll, Kun Zhao, Marika Geleishvili, Crystal M. Gigante, Ginny L. Emerson, Ekaterine Khmaladze, Shiyuyun Tang, Yu Li, Whitni Davidson, Jinxin Gao, Maka Kokhreidze, Yoshinori Nakazawa, Giorgi Maghlakelidze, Pengbo Liu, Kimberly Wilkins |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Old World Sequence analysis cowpox virus orthopoxvirus Genome Viral Genome Article 03 medical and health sciences Virology Akhmeta virus Orthopoxvirus Monkeypox virus Phylogeny Recombination Genetic Whole genome sequencing Genetics Whole Genome Sequencing biology Phylogenetic tree Cowpox virus Sequence Analysis DNA Variola virus biology.organism_classification recombination Africa Western Phenotype 030104 developmental biology Infectious Diseases Congo DNA Viral |
Zdroj: | Viruses; Volume 10; Issue 5; Pages: 252 Viruses |
ISSN: | 1999-4915 |
DOI: | 10.3390/v10050252 |
Popis: | Annotated whole genome sequences of three isolates of the Akhmeta virus (AKMV), a novel species of orthopoxvirus (OPXV), isolated from the Akhmeta and Vani regions of the country Georgia, are presented and discussed. The AKMV genome is similar in genomic content and structure to that of the cowpox virus (CPXV), but a lower sequence identity was found between AKMV and Old World OPXVs than between other known species of Old World OPXVs. Phylogenetic analysis showed that AKMV diverged prior to other Old World OPXV. AKMV isolates formed a monophyletic clade in the OPXV phylogeny, yet the sequence variability between AKMV isolates was higher than between the monkeypox virus strains in the Congo basin and West Africa. An AKMV isolate from Vani contained approximately six kb sequence in the left terminal region that shared a higher similarity with CPXV than with other AKMV isolates, whereas the rest of the genome was most similar to AKMV, suggesting recombination between AKMV and CPXV in a region containing several host range and virulence genes. |
Databáze: | OpenAIRE |
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