Facile Hydrogenative Deprotection of N‑Benzyl Groups Using a Mixed Catalyst of Palladium and Niobic Acid-on-Carbon

Autor:	Eisho Shimizu, Wada Yoshiyuki, Yoshinari Sawama, Tomoteru Mizusaki, Yuta Yamamoto, Hironao Sajiki, Masatoshi Yoshimura, Kazuho Ban, Yukio Takagi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	inorganic chemicals Chemistry organic chemicals General Chemical Engineering Combined use chemistry.chemical_element General Chemistry Heterogeneous catalysis Article Catalysis medicine Organic chemistry heterocyclic compounds Carbon QD1-999 Palladium Activated carbon medicine.drug
Zdroj:	ACS Omega, Vol 5, Iss 6, Pp 2699-2709 (2020) ACS Omega
ISSN:	2470-1343
Popis:	The palladium-on-carbon (Pd/C)-catalyzed hydrogenative deprotection of the N-benzyl-protecting group was effectively facilitated by the combined use of niobic acid-on-carbon (Nb2O5/C). Nb2O5/C is an acidic heterogeneous catalyst prepared from NbCl5 and activated carbon. The catalysts were easily removed from the reaction mixture and reusable. Deprotected amines were obtained in excellent yields without an additional neutralization process. The facilitating effect of Nb2O5/C was also observed during the Pd/C-catalyzed hydrogenative deprotection of the N-benzyloxycarbonyl (Cbz) and O-benzyl groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825b2f52af895e23e40798ddf03269c3 https://doaj.org/article/2a6557b508d742b98e4d03bf27af43e8 Zobrazit plný text záznamu