Role for endocannabinoids in early pregnancy: recent advances and the effects of cannabis use
| Autor: | Henry C Ezechukwu, Deanne H. Hryciw, Nirajan Shrestha, Cornelius A. Diya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Cannabinoid receptor Physiology Endocrinology Diabetes and Metabolism Marijuana Smoking Medical Marijuana Bioinformatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Physiology (medical) Internal medicine Humans Medicine Reproductive system Effects of cannabis biology business.industry Decidualization Anandamide medicine.disease biology.organism_classification Endocannabinoid system 030104 developmental biology Endocrinology chemistry Female lipids (amino acids peptides and proteins) Cannabis business 030217 neurology & neurosurgery Endocannabinoids |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 319:E557-E561 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.00210.2020 |
| Popis: | The endocannabinoid system (ECS) is associated with several physiological processes, including reproduction. This system consists of the cannabinoid receptors, endocannabinoid ligands, and enzymes that metabolize and degrade these fatty acids. Recent evidence shows that cannabinoid receptors are expressed in cells of the reproductive system, including endometrial stromal cells, ovaries, and sperm cells. Emerging and recent research suggests that the ECS may play a significant role in reproduction. The endocannabinoid ligands anandamide and 2-arachidonoylglycerol are crucial for successful endometrium decidualization, placental development, and embryo implantation. Alteration in cannabinoid receptor expression or in endocannabinoid homeostasis by excessive intake of cannabis during pregnancy is associated with negative pregnancy outcomes, including preterm birth. The use of medicinal cannabis is becoming more widespread in Western countries, especially in people of reproductive age. Cannabis contains phytocannabinoids, which modulate the ECS, and emerging evidence suggests that phytocannabinoids, through their action on cannabinoid receptors, may have a negative impact on fertility, pregnancy outcome, and fetal health. In this mini-review, we highlight the recent advances in the field, which explore the role of endocannabinoids in early pregnancy and the effects of excessive intake of phytocannabinoids in pregnancy outcomes. |
| Databáze: | OpenAIRE |
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