Preliminary data of a prospective study on neuropsychiatric side effects after initiation of efavirenz
| Autor: | Araceli Rousaud, Joan de Pablo, Jordi Blanch, Josep M. Gatell, Miguel-Ángel García-Viejo, Esteban Martínez, Josep Mallolas, Elisa de Lazzari, Josep-Maria Peri, Jose-Luis Blanco |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Cyclopropanes Male medicine.medical_specialty Patient Dropouts Anti-HIV Agents HIV Infections Neuropsychological Tests Quality of life Internal medicine Oxazines Medicine Humans Pharmacology (medical) Prospective Studies Prospective cohort study Depression (differential diagnoses) business.industry Middle Aged medicine.disease Discontinuation Benzoxazines Regimen Distress Infectious Diseases Alkynes Immunology Anxiety Educational Status Reverse Transcriptase Inhibitors Female medicine.symptom business Somatization |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 27(4) |
| ISSN: | 1525-4135 |
| Popis: | Objective: To assess baseline variables able to predict neuropsychiatric side effects (NPSEs) associated with the initiation of an efavirenz (EFV)-containing regimen in HIV-1-infected patients. Design: Open-label, prospective, observational study. Methods: Consecutive HIV-1-infected outpatients in whom EFV was prescribed underwent a psychiatric interview. At baseline and at 2, 4, and 12 weeks, patients completed the Symptoms Check List-90-Revised (SCL-90-R), the Medical Outcome Study for HIV-positive patients (MOS-HIV), and a standardized questionnaire concerning potential NPSEs. Results: Preliminary data showed that discontinuation of EFV because of NPSEs occurred in 4 of 31 patients (13%). Patients who completed the follow-up showed a decrease in SCL-90-R total score (p = .004) and in several subscales such as Interpersonal Sensitivity (p = .009), Depression (p = .001), and Anxiety (p = .040), whereas no changes in MOS-HIV were observed. Having fewer years of education (p = .006), having fewer baseline central nervous symptoms (p = .000), reporting better baseline physical status (p = .013), and having higher baseline scores in the Heath Transition subscale of the MOS-HIV (p = .000) and in the Somatization subscale of the SCL-90-R (p = .002) were associated with more NPSEs. Conclusion: Patients maintained on EFV showed a decrease in psychologic distress related to self-image, depression, and anxiety, without any effect on quality of life. Patients with a lower level of education, those who feel physically and psychologically better at baseline than in the past, and those who suffer from more distress as a result of physical complaints may be at greater risk of reporting more NPSEs after EFV initiation. |
| Databáze: | OpenAIRE |
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