Did TCDD exposure or service in Southeast Asia increase the risk of cancer in air force Vietnam veterans who did not spray agent orange?
| Autor: | Marian Pavuk, Fatema Z. Akhtar, Joel E. Michalek, Karen Fox, Arnold Schecter, Norma S. Ketchum |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Polychlorinated Dibenzodioxins Time Factors Body Mass Index Occupational medicine chemistry.chemical_compound Prostate cancer Risk Factors Environmental health Neoplasms Medicine Humans heterocyclic compounds Risk factor Melanoma reproductive and urinary physiology business.industry Proportional hazards model Incidence (epidemiology) Agent Orange Incidence Public Health Environmental and Occupational Health Cancer Prostatic Neoplasms medicine.disease United States stomatognathic diseases Military Personnel chemistry Vietnam Relative risk Environmental Pollutants business SEER Program |
| Zdroj: | Journal of occupational and environmental medicine. 47(4) |
| ISSN: | 1076-2752 |
| Popis: | Objective We sought to examine cancer incidence in 1482 Air Force veterans who served in Southeast Asia (SEA) and who were not occupationally exposed to herbicides. Methods Cancer incidence between 1982 and 2003 was determined by record review and Cox proportional hazards models were used to estimate risk ratios across serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and years served in SEA categories. Results All sites cancer risk increased with TCDD (relative risk = 1.6, 95% confidence interval = 1.2-2.2). The risk of prostate cancer increased with years of SEA service but not with TCDD. TCDD and years of SEA service interacted with all sites cancer; the risk was greatest in those with the highest TCDD levels and the longest time served in SEA. Conclusions These results suggest nonoccupational exposures to TCDD or other factors while in SEA may contribute to cancer risk in these veterans. |
| Databáze: | OpenAIRE |
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