Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism
| Autor: | G. Gross, H.J. Schümann, E. Borowski |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Atropine
Male medicine.medical_specialty Adrenergic receptor Tubocurarine Stimulation Blood Pressure Clonidine Norepinephrine Phenylephrine Hypothyroidism Heart Rate Isoprenaline Internal medicine Heart rate Receptors Adrenergic beta medicine Animals Pharmacology business.industry Bupranolol Isoproterenol Receptors Adrenergic alpha Electric Stimulation Rats Receptors Adrenergic Disease Models Animal Endocrinology Blood pressure Spinal Cord Propylthiouracil Thyroid hormones Reflex business medicine.drug |
| Zdroj: | European journal of pharmacology. 56(1-2) |
| ISSN: | 0014-2999 |
| Popis: | Adrenoceptor-mediated responses of the cardiovascular system during propylthiouracil-induced hypothyroidism were investigated. Interfering nervous reflexes could be circumvented by using pithed rats. Cardiac beta-adrenoceptor-mediated acceleration of heart rate following electrical stimulation or injection of noradrenaline and isoprenaline was markedly diminished even after 2 weeks of treatment. This loss of beta-sensitivity prevented the study of possible changes of presynaptic regulatory adrenoceptors in this test model. Taking the increase in diastolic blood pressure after application of alpha-agonists as index of the sensitivity of vascular alpha-adrenoceptors we found these to have been desensitized in the hypothyroid state. According to these results the lack of thyroid hormones exerted a similar effect on cardiac beta- and on vascular alpha-adrenoceptors. |
| Databáze: | OpenAIRE |
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