Depressive symptoms and cortisol variability prior to surgery for suspected endometrial cancer
| Autor: | Linda S. Morgan, Stephanie Garey Smith, Michael Marsiske, Shawn M. Kneipp, Stacy M. Dodd, Deidre B. Pereira, Susan M. Lutgendorf, Seema M. Patidar, Timothy S. Sannes, Sally E. Jensen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Hypothalamo-Hypophyseal System
medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Population Individuality Pituitary-Adrenal System Anxiety Article Arousal Endocrinology medicine Humans Saliva education Biological Psychiatry Depression (differential diagnoses) education.field_of_study Models Statistical Depression Endocrine and Autonomic Systems business.industry Endometrial cancer Cancer Middle Aged medicine.disease Circadian Rhythm Endometrial Neoplasms Surgery Psychiatry and Mental health Mood Female Symptom Assessment medicine.symptom business medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 38:241-249 |
| ISSN: | 0306-4530 |
| Popis: | Endometrial cancer (EC) is the most common type of gynecologic cancer affecting women; however, very little research has examined relationships between psychological factors and hypothalamic-pituitary-adrenal (HPA) axis dysregulation in this population. The current study examined relations between depressive/anxious symptoms and salivary cortisol diurnal rhythm and variability in women undergoing surgery for suspected endometrial cancer. Depressive and anxious symptoms were measured prior to surgery using the Structured Interview Guide for the Hamilton Depression Inventory (SIGH-AD). Saliva was collected four times a day for the three days prior to surgery and then assayed by ELISA to obtain cortisol concentrations. Cortisol slopes and intraindividual variability were then calculated across subjects. Relations between depressive/anxious symptoms and cortisol indices were examined using multilevel modeling and linear regression analyses. Participants were 82 women with nonmetastatic endometrial cancer. Anxious symptoms were not associated with either cortisol slope or intraindividual variability, and depressive symptoms were unrelated to cortisol slope. However, after controlling for presence of poorer prognosis cancer subtypes, greater depressive symptoms (excluding symptoms possibly/definitely due to health/treatment factors) in the week preceding surgery were significantly related to greater cortisol intraindividual variability (β=.214; p |
| Databáze: | OpenAIRE |
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