Skin Fibroblasts as the Object for Clinical Diagnosis of Parkinson's Disease in Persons of Different Ages
| Autor: | I. M. Kvetnoi, V. A. Zuev, N.N. Belushkina, A. S. Dyatlova, Natalia Linkova, V A Pal'tsev |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Parkinson's disease Substantia nigra Disease Neuropathology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Elderly persons Medicine Humans Aged Skin Aged 80 and over Amyloid beta-Peptides business.industry Age Factors Parkinson Disease General Medicine Fibroblasts Middle Aged medicine.disease nervous system diseases 030104 developmental biology nervous system Clinical diagnosis alpha-Synuclein Immunohistochemistry α synuclein Female business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Bulletin of experimental biology and medicine. 167(1) |
| ISSN: | 1573-8221 |
| Popis: | We compared the expression of Aβ42 peptide, τ-protein, and α-synuclein in the substantia nigra and skin fibroblasts of elderly and senile patients with Parkinson's disease and subjects without neuropathology. Expression of markers in the studied tissues was assessed by immunohistochemical and immunocytochemical methods. The expression of Aβ42 peptide, τ-protein, and α-synuclein in the substantia nigra of elderly and senile patients with Parkinson's disease was higher by 11-31 times than in subjects without neuropathology. In skin fibroblasts of patients with Parkinson's disease, the expression of Aβ42 peptide and α-synuclein was 3-14 times higher than in subjects without neuropathology, and expression of τ-protein did not significantly differ in the studied groups. Thus, immunocytochemical analysis of the expression Aβ42 peptide and α-synuclein in skin fibroblasts can be a simple method of early diagnosis of Parkinson's disease in elderly persons. |
| Databáze: | OpenAIRE |
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