The relationship between thermodynamics and the toxicity of gadolinium complexes
| Autor: | Steven C. Quay, William P. Cacheris, Scott M. Rocklage |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Gadolinium DTPA
Male Stereochemistry Gadolinium Biomedical Engineering Biophysics Contrast Media chemistry.chemical_element Median lethal dose Lethal Dose 50 Metal Mice Transmetalation In vivo Organometallic Compounds Animals Radiology Nuclear Medicine and imaging Edetic Acid Chemistry Rats Inbred Strains Pentetic Acid Magnetic Resonance Imaging Acute toxicity Rats visual_art Toxicity visual_art.visual_art_medium Thermodynamics Female Chemical stability |
| Zdroj: | Magnetic Resonance Imaging. 8:467-481 |
| ISSN: | 0730-725X |
| Popis: | The suitability of gadolinium complexes as magnetic resonance imaging contrast agents depends on a number of factors. A thermodynamic relationship to toxicity exists if one assumes that the chemotoxicity of the intact complex is minimal but that the toxicity of the components of the complex (free metal and uncomplexed ligands) is substantial. Release of Gd3+ from the complex is responsible for the toxicity associated with gadolinium complexes; this release appears to be a consequence of Zn2+, Cu2+, and Ca2+ transmetallation in vivo. This hypothesis is supported by acute toxicity experiments, which demonstrate that despite a 50-fold range of LD50 values for four Gd complexes, all become lethally toxic when they release precisely the same quantity of Gd3+, and by subchronic rodent toxicity experiments, which demonstrate a set of gross and microscopic findings similar to those known to be caused by Zn2+ deficiency. Finally, this hypothesis predicts that subtle changes in formulation can further enhance the intrinsic safety of these complexes. |
| Databáze: | OpenAIRE |
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