KIR3DS1 directs NK cell-mediated protection against human adenovirus infections
| Autor: | Kristina Russu, Christian Körner, Mirjam E Belderbos, Kimberly J. Möller, Suze A. Jansen, Mareike Ohms, Annika Niehrs, Ingo Königs, Anja Ehrhardt, Johannes M. Jung, Lucy Wegner, Martin E. Baumdick, Helga Hofmann-Sieber, Thomas Dobner, Marc Lütgehetmann, Madeleine J. Bunders, Wilhelm Ching, Marcus Altfeld, Angelique Hölzemer, Kevin Duisters, Caroline A. Lindemans, Sven Peine, Tobias Koyro, Wenli Zhang, Daniel Perez, Jens B. Bosse, Eric Spierings, Konrad Reinshagen |
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| Rok vydání: | 2021 |
| Předmět: |
Human Adenoviruses
Receptors KIR3DS1 business.industry medicine.medical_treatment Adenoviruses Human Immunology General Medicine Hematopoietic stem cell transplantation Disease Cell mediated immunity Adenovirus Infections Human Killer Cells Natural HEK293 Cells A549 Cells medicine Cancer research Humans business |
| Zdroj: | Science immunology. 6(63) |
| ISSN: | 2470-9468 |
| Popis: | Human adenoviruses (HAdVs) are a major cause for disease in children, in particular after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Currently, effective therapies for HAdV infections in immunocompromised hosts are lacking. To decipher immune recognition of HAdV infection and determine new targets for immune-mediated control, we used an HAdV infection 3D organoid system, based on primary human intestinal epithelial cells. HLA-F, the functional ligand for the activating NK cell receptor KIR3DS1, was strongly up-regulated and enabled enhanced killing of HAdV5-infected cells in organoids by KIR3DS1 |
| Databáze: | OpenAIRE |
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