Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFα
| Autor: | Deguang Yang, Xiuping Liu, Chunhong Li, Changyun Xiong |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Human neutrophil
Neutrophils bcl-X Protein Biomedical Engineering Neutrophil apoptosis Apoptosis Bcl-xL Biochemistry Proinflammatory cytokine Biomaterials Genetics Humans Cells Cultured Earth-Surface Processes Interleukin-15 biology Tumor Necrosis Factor-alpha Chemistry Cell biology Blot Proto-Oncogene Proteins c-bcl-2 Interleukin 15 biology.protein Cancer research Tumor necrosis factor alpha |
| Zdroj: | Journal of Huazhong University of Science and Technology. 27:354-357 |
| ISSN: | 1993-1352 1672-0733 |
| DOI: | 10.1007/s11596-007-0402-9 |
| Popis: | Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFalpha was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFalpha was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFalpha might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFalpha can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course. |
| Databáze: | OpenAIRE |
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