Review of controversies in management of non-benign meningioma
| Autor: | Andrew H. Kaye, Yuval Z. Sufaro, Iddo Paldor, Mohammed Awad, Yigal Shoshan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Antineoplastic Agents Extent of resection World health Meningioma 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Physiology (medical) Grade II Meningioma otorhinolaryngologic diseases medicine Humans neoplasms Grade III Meningioma Brain Neoplasms business.industry General Medicine medicine.disease Combined Modality Therapy nervous system diseases Surgery Radiation therapy Neurology 030220 oncology & carcinogenesis Benign Meningioma Neurology (clinical) Neoplasm Recurrence Local business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Neuroscience. 31:37-46 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2016.03.014 |
| Popis: | Meningiomas are one of the most common brain tumors. World Health Organisation (WHO) Grade II and Grade III meningiomas are grouped together as non-benign meningioma (NBM). There are several controversies surrounding NBM management, including the significance of extent of resection and the efficacy of post-operative radiation and drug treatment. We reviewed the literature to develop recommendations for management of NBM. The questions we sought to answer were: Does gross total resection (GTR) improve patient outcome? Is radiation therapy (RT) warranted after complete or after incomplete resection of NBM? What drug therapies have been proven to improve outcome in patients with NBM? We found that GTR improves outcome in WHO Grade II meningioma, and should be attempted whenever considered safe. GTR correlates less closely to outcome in Grade III meningioma compared to subtotal resection (STR). Extreme measures to completely resect Grade III meningioma are not warranted. RT following GTR of Grade II meningioma does not improve patient outcome, and may be reserved for recurrence. RT improves outcome following STR of Grade II meningioma. RT improves outcome after resection of Grade III meningioma. No drug therapy has been shown to improve outcome in NBM. This review elucidates recommendations for some of the controversies involving NBM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect