Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: The role of comorbidities and environmental factors

Autor: Regina Rückerl, Annette Peters, Timo Lanki, Fredrik Nyberg, Jordi Sunyer, Mariarita Andreani, Natalie Khuseyinova, Wolfgang Koenig, Konstantina Dimakopoulou, Alexandra Schneider, Christa Meisinger
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Adult
Male
medicine.medical_specialty
Clinical Biochemistry
Myocardial Infarction
Type 2 diabetes
Comorbidity
Gastroenterology
Tobacco smoke
Body Mass Index
Angina
particulate air-pollution
coronary-heart-disease
cardiovascular-disease
systemic inflammation
general-population
markers
risk
association
Augsburg
men
Sex Factors
Risk Factors
Internal medicine
Air Pollution
Surveys and Questionnaires
medicine
Humans
Myocardial infarction
Longitudinal Studies
Prospective Studies
cardiovascular diseases
Aged
Aged
80 and over
Glycated Hemoglobin
biology
business.industry
Biochemistry (medical)
C-reactive protein
Smoking
Acute-phase protein
nutritional and metabolic diseases
Middle Aged
medicine.disease
Surgery
C-Reactive Protein
Socioeconomic Factors
Heart failure
Data Interpretation
Statistical
biology.protein
Female
business
Blood sampling
Zdroj: Clin. Chem. 55, 322-335 (2009)
Popis: Background: C-reactive protein (CRP), a sensitive marker of the acute-phase response, has been associated with future cardiovascular endpoints independently of other risk factors. A joint analysis of the role of risk factors in predicting mean concentrations and variation of high-sensitivity CRP (hsCRP) in serum has not been carried out previously. Methods: We used data from 1003 myocardial infarction (MI) survivors who had hsCRP measured monthly up to 8 times and multivariate mixed effects statistical models to study the role of time-variant and -invariant factors on the geometric mean of and the intraindividual variation in hsCRP concentrations. Results: Patients with ≥6.5% glycosylated hemoglobin (HbA1c) had 26.2% higher hsCRP concentrations (95% CI, 7.2%–48.6%) and 20.7% greater variation in hsCRP values (P = 0.0034) than patients with lower baseline Hb A1c values ( Conclusions: One or 2 hsCRP measurements may not be sufficient to adequately characterize different patient groups after MI with similar precisions. We found hsCRP concentrations to be especially variable in males, smokers, and patients with increased Hb A1c values.
Databáze: OpenAIRE
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