Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study
| Autor: | Pavol Mikolas, Ibrahim Ibrahim, Natalie Görnerova, Jaroslav Tintera, Andrea Slovakova, Filip Spaniel, Marketa Fialova, Jiri Horacek, Tomáš Kašpárek, Tomas Hajek, Yuliya Zaytseva, Tomas Melicher, Jan Rydlo, Martin Matejka, Cyril Höschl |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Prefrontal Cortex Motor Activity behavioral disciplines and activities Gyrus Cinguli 050105 experimental psychology Perceptual Disorders 03 medical and health sciences 0302 clinical medicine Neuroimaging medicine Connectome Humans 0501 psychology and cognitive sciences Prefrontal cortex Default mode network medicine.diagnostic_test 05 social sciences Magnetic resonance imaging Regular Article Medial frontal gyrus Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Schizophrenia Female Nerve Net Psychology Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | Schizophrenia bulletin. 42(4) |
| ISSN: | 1745-1701 |
| Popis: | Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes. |
| Databáze: | OpenAIRE |
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