Dynamics of markers of markers of acute kidney injury when using epidural block during resection under warm ischemia
| Autor: | O. I. Kit, E. M. Frantsiyants, D. A. Rozenko, N. D. Ushakova, S. N. Dimitriadi, Yu. A. Pogorelova, N. D. Cheryarina, L. S. Kozlova, K. P. Boyko, V. V. Gurnak |
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| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Urology medicine.medical_treatment renal cancer Ischemia biomarker of acute kidney injury epidural block Blood serum medicine Radiology Nuclear Medicine and imaging Kidney biology business.industry Acute kidney injury Perioperative medicine.disease Nephrectomy medicine.anatomical_structure Oncology Cystatin C Nephrology biology.protein Medicine Surgery Interleukin 18 business |
| Zdroj: | Onkourologiâ, Vol 13, Iss 4, Pp 25-33 (2018) |
| ISSN: | 1996-1812 1726-9776 |
| Popis: | Objective: to investigate the time course of changes in the early biomarkers of acute kidney injury in patients with clinically localized cancer during partial nephrectomy, as electively indicated, under thermal ischemia with prior epidural block.Materials and methods. To analyze the nephroprotective effect of an epidural block in kidney resection with warm ischemia, markers of acute kidney injury (cystatin C, interleukin 18, NGAL, L-FABP and KIM-1) were studied by ELISA in the blood and urine of 35 patients with local cancer with an epidural block (main group) and 37 patients with local cancer without an epidural block (control group) before surgery and 40 min after its beginning and on days 1 and 3 of the postoperative period. All patients were divided into 2 groups by the levels of cystatin C in the blood serum: 1000 ng/ml and lower, and over 1000 ng/ml.Results. Epidural block during the perioperative period in kidney resection with warm ischemia for patients with local cancer had an obvious nephroprotective effect allowing maintaining the initial renal functional parameters, in contrast to the standard disease management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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