AT2433-A1, AT2433-A2, AT2433-B1, and AT2433-B2 novel antitumor antibiotic compounds produced by Actinomadura melliaura. Taxonomy, fermentation, isolation and biological properties
| Autor: | Mahesh Patel, Bush James A, C. A. Claridge, Ann C. Horan, James A. Matson, Jeffery Titus, William T. Bradner, Terrence W. Doyle |
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| Rok vydání: | 1989 |
| Předmět: |
Nocardiaceae
Indoles Chemical Phenomena Rebeccamycin Carbazoles Micrococcus Microbial Sensitivity Tests Bacillus subtilis medicine.disease_cause Indolocarbazole Microbiology Mice chemistry.chemical_compound Drug Discovery medicine Animals Actinomadura Chromatography High Pressure Liquid Soil Microbiology Pharmacology Antibiotics Antineoplastic Molecular Structure biology Chemistry Physical Leukemia P388 biology.organism_classification Anti-Bacterial Agents Aminoglycosides Biochemistry chemistry Staphylococcus aureus Fermentation Chromatography Gel Actinomycetales Bacteria medicine.drug |
| Zdroj: | The Journal of Antibiotics. 42:1547-1555 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.42.1547 |
| Popis: | Compounds AT2433-A1 (A1), AT2433-A2 (A2), AT2433-B1 (B1), and AT2433-B2 (B2) were isolated from the cultured broth of Actinomadura melliaura sp. nov. (SCC 1655). Structurally these materials are closely related to rebeccamycin (1), an indolocarbazole antitumor antibiotic. A1, A2, B1, and B2 were active against Staphylococcus aureus A9537, Streptococcus faecalis A20688, Streptococcus faecium (ATCC 9790), Micrococcus lutea (ATCC 9341), Bacillus subtilis (ATCC 6633). A1 and B1 were active against P388 leukemia in mice. |
| Databáze: | OpenAIRE |
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