Effect of orally administered alpha-tocopheryl acetate on human myocardial alpha-tocopherol levels
| Autor: | Graham W. Burton, Donald A. G. Mickle, Keith U. Ingold, Richard D. Weisel |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_treatment
alpha-Tocopherol oral drug administration Alpha (ethology) Administration Oral Tocopherols Myocardial Reperfusion Revascularization alpha tocopherol Preoperative care chemistry.chemical_compound angina pectoris Preoperative Care medicine Humans Vitamin E Pharmacology (medical) Tocopherol isotope labeling Coronary Artery Bypass deuterium conference paper Pharmacology clinical article business.industry Myocardium General Medicine support non-U.S. gov't heart left ventricle reperfusion medicine.anatomical_structure chemistry priority journal Anesthesia bypass surgery Tocopheryl acetate Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Cardiovascular drugs and therapy. 5 |
| ISSN: | 0920-3206 |
| Popis: | Free radical injury may contribute to the delayed postoperative recovery of myocardial metabolism and ventricular function after elective coronary artery revascularization. This clinical study was designed to evaluate, in stable angina patients having aortocoronary bypass surgery [1], whether orally administered alpha-tocopheryl acetate was effective in increasing myocardial alpha-tocopherol levels and [2] the effect of cardioplegic arrest followed by reperfusion on the myocardial alpha-tocopherol levels. Twenty-four patients with stable angina pectoris for elective revascularization received preopertatively the natural stereoisomer of alpha-tocopheryl acetate labelled with deuterium (D3) and six patients were used as controls. Since four patients who received 300 mg of D3-alpha-tocopheryl acetate preoperatively for 1 and 2 days did not have significant increases in their myocardial total or D3-tocopherol levels, the remaining 20 patients received 100 mg (n=6), 300 mg (n=8), or 900 mg (n=6) of D3-alpha-tocopheryl acetate for 14 consecutive preoperative days. The left ventricular deuterated and non-deuterated alpha-tocopherol levels were measured by gas chromatography/mass spectrometry. Although there was a decrease (p < 0.05) in myocardial alpha-tocopherol levels with the onset of reperfusion (cross-clamp removal), the myocardial tocopherol levels were not statistically different from preoperative levels by 20 minutes of reperfusion. At least 300 mg of alpha-tocopherol must be taken orally for 14 consecutive days to double the myocardial alpha-tocopherol levels. © 1991 Kluwer Academic Publishers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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