Prevalence of Hb S (HHB: c.20A T) in a Honduran population of African descent

Autor:	Néstor J. Yanez, Gustavo Fontecha, Brian M. Erazo, Linda E. Cerrato, Edder J. Castro, Luis J. Pinto, Brayan Montoya, Gilberto A. Ramirez
Rok vydání:	2015
Předmět:	Male Adolescent Anemia African descent Clinical Biochemistry Population Hemoglobin Sickle Black People Disease Anemia Sickle Cell beta-Globins Young Adult Gene Frequency Pregnancy medicine Prevalence Humans education Child Allele frequency Genetics (clinical) Sickle Hemoglobin education.field_of_study High prevalence Geography Biochemistry (medical) Homozygote Infant Hematology medicine.disease Hemoglobinopathy Honduras Child Preschool Mutation Female Polymorphism Restriction Fragment Length Demography
Zdroj:	Hemoglobin. 39(2)
ISSN:	1532-432X
Popis:	Sickle cell disease is the most common hemoglobinopathy worldwide, particularly in Africa and among people of African descent. Serious clinical consequences characterize the homozygous condition. To determine the prevalence of Hb S (HBB: c.20A > T) and anemia in a community of people of African descent from Honduras, 202 individuals were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The high prevalence found indicates that it is necessary to implement a program to prevent the consequences of this disease in vulnerable populations of Honduras.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824c7b9579bd2fa676e24b28979b4234 https://pubmed.ncbi.nlm.nih.gov/25707678 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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